News

we would like to announce our next "LAP-Life after PhD" seminar which will take place on July, 21 at 4:30 p.m. as an online seminar.

Our speaker will be Dr. Claudia Reschke, a former „Personal Assistant to the Scientific Director of DKFZ“ and now „Adviser Helmholtz Information & Data Science Academy (HIDA)“, the Helmholtz Information and Data Science Academy. She will talk about both her career path from her PhD to Science Management and the activities of the HIDA which offers extensive training in Information and Data Science to doctoral researchers and postdocs.

Date: July, 21st
Time: 4:30 p.m.
Venue: Zoom

Room and password upon reasonable request (contact: compcancer at charite dot de). You will find regular updates at https://www.regulatory-genome.hu-berlin.de/en/events/lectures/lap-series.

We are delighted to announce our next LAP seminar. This time Wiebke Skeffington, who is coordinating the IRTG2403 will speak about her career. Wiebke studied biology and during her career spent time in the US and UK and by now switched from research to research management.

Date: June, 23rd
Time: 4:30 p.m.
Venue: Zoom (https://zoom.us/j/878362909)
Speaker: Wiebke Skeffington - program coordinator

In addition to speaking about her own career, Wiebke will also give tips and tricks how to apply successfully for a postdoc position.

Password upon reasonable request (contact: compcancer at charite dot de). You will find regular updates at https://www.regulatory-genome.hu-berlin.de/en/events/lectures/lap-series.

https://www.biorxiv.org/content/10.1101/2020.06.12.146811v2

In the wake of the multi-omics era, stratification of cancer entities at multiple molecular levels have become increasingly prominent for diagnostic and therapeutic purposes. By uncovering the diversity within a cancer entity, we can understand inter-tumor heterogeneity as well as the biological mechanism contributing to it. Our study presents an integrative multi-omics approach that classifies pancreatic neuroendocrine neoplasms (PanNENs) subgroups, highlights cell-of-origin distinction, as well as differences in multi-genomic aberration and proteomic changes grounded within these subgroups. We determined that PanNEN tumor methylome profile closely resembles either α-like and β-like cells of Islet of Langerhans. The most aggressive tumor grades of PanNEN contain β-cell features and show hypermethylation of various transcription factors involved in Islet cell differentiation and maintenance. Mutations within MEN1/DAXX/ATRX tumor suppressor genes and overexpression of mTOR pathway proteins are key features of α-like tumors. DNA copy number data further implicates differences in tumor progression mechanism within the α-like tumors. Taken together, our data provides new insights into the PanNEN heterogeneity and further establishes a foundation for future diagnostic and therapy-relevant patient stratification.

Berlins Bioinformatic social meeting, which is supported by CompCancer, went virtual as well. The next gathering is this Wednesday, May 27th, at 5 pm.

The speakers will be:

Jakub Bartoszewicz (RKI / HPI) – “Sequence-based detection of novel pathogens using interpretable deep learning” 

Jessica Zhou (University of California San Diego / BIMSB / HPI) – “Characterizing the activity of multiple regulatory elements and interactions between them by analyzing multiplexed single cell CRISPR regulatory screens”

All meetings with the Zoom-ID and password are announced on the mailing list https://lists.fu-berlin.de/listinfo/compbio-social

After a short break the series LAP – Life after PhD is back. We are inviting different people who have done their PhD and moved on in various directions. Careers in industry, education, science and health etc. will be introduced and they will share their experiences and decisions for their career moves. On May 5th we have Ralf Bortfeldt, who works as a Bioinformatician and IT-Manager at IFN Schönow, as a guest in our webinar.

Date: May 5th
Time: 4:30 p.m.
Venue: Zoom
Speaker: Ralf Bortfeldt – IT manager

Password upon reasonable request (contact: compcancer at charite dot de). You will find regular updates at https://www.regulatory-genome.hu-berlin.de/en/events/lectures/lap-series.