News

New webinar: Cancer and Immunology

We are starting a new webinar series "Cancer and Immunology" for CompCancer PhD students. The series is part of  the qualification program and aims to introduce some biological background relevant for research questions within CompCancer.

Date: March 25th / April 2nd
Time: 3:30 p.m.
Venue: Zoom
Speaker: Markus Morkel

Abstract:

Colorectal Cancer (CRC) is driven by oncogenic mutations that deregulate signaling networks governing cell turnover in the colon epithelium. These two lectures give an overview of cell signal transduction, clinical features and cell heterogeneity in CRC.

Date: March 26th
Time: 3:30 p.m.
Venue: Zoom
Speaker: Philip Bischoff

Diagnostic standard procedures in the Institute of Pathology

In this session you will get to know the general workflow in diagnostic pathology, how samples are processed until the pathologist makes the diagnosis and how this affects the therapy of the patient. Taking colorectal cancer as an example, I will give a quick introduction to histology using standard H&E stainings and immunostainings.

LAP - Life after PhD seminar

The Ph.D. programs of the IRI for Life Sciences are joining forces and in March we are starting a new series: LAP – Life after Ph.D. We are inviting different people who have done their Ph.D. and moved on in various directions. Careers in industry, education, science, health, and more will be introduced and they will share their experiences and decisions for their career moves. We hope that you will get new ideas, get inspired and see that there are so many options open to you after you have finished your Ph.D.
You will find more information at

https://www.regulatory-genome.hu-berlin.de/en/events/lectures/lap-series.

While COVID-19 takes control of our working life, we will hold the first webinar of our "LAP - Life after Ph.D." series with Joram Schwartzmann, Science Communicator, on Tuesday, 17 March at 4:30 p.m.

Science communication in the heart of Brussels

Report by Torsten Gross

A diverse group of young European researchers gathered in Brussels for the Standing up for Science workshop. We discussed the relationship between science and journalism, learned how scientific evidence supports the legislation of the European Commission, and explored our own possibilities for public outreach.

The value of science for society is evident for any researcher. But to promote it, the research community needs to actively engage in public debate. How this can be done was vividly discussed on March 6th in Brussels at the Standing up for Science EU workshop organized by the independent charity Sense about Science. Thanks to the support from the CompCancer PhD programme, I could join a group of about 30 European PhD students and PostDocs and participated in a series of panel discussions and team projects. Over the course of the day, we met science communicators, science journalists, and members of the European Commission.

We as scientists might hold a preconception that our work will eventually speak for itself. But Liesbeth Aerts, who is an active participant in the debate on animal testing, made clear that: ''if you don't speak up, no one else will''. Evolutionary geneticist Maarten Larmuseau agreed and added that public engagement can even feed back into your own research. After he started writing newspaper articles and blog posts, citizens approached him to have their DNA sequenced.

Yet academics and journalists need to bridge a cultural divide, as remarked by science writer Catherine Collins. For instance, a science news article or feature must immediately convey why the subject matter is important to the general audience. Nicholas Wallace made it clear: ''One of the top three sentences should be the 'why should I care?' sentence." Also, Pauline Bock explained that if you do not answer emails immediately, journalists will not be able to reach their deadlines and lose interest in you.

Particularly interesting insides story were then given by Jeremy Bray and Toby Wardman from the Scientific Advice Mechanism of the European Commission. They explained how the Commission brings together scientists from over 100 academies and societies across Europe so that policy decisions can be based on scientific evidence.

We continued the discussion in some of Brussels many pubs and restaurants until early in the morning. As we shared our stories and made new friends, I understood that in order to base future public debates on evidence, the scientific community needs to speak up.

Guest speaker: Roi Avraham

On March 5th we have another talk in the new series on “Heterogeneity in Biological Systems” in the framework of our IRI-Colloquium: Roi Avraham from the Weizmann Institute of Science (http://www.weizmann.ac.il/Biological_Regulation/avraham/avraham-lab-homepage) will give a talk on “Predicting human infection outcome using single cell RNA-seq of blood immune cells“. 

Date: March 5th

Time: 4 p.m.

Venue: IRI Life Sciences
Humboldt-Universität zu Berlin
Philippstr. 13
Michaelis Building (No 18)
Maud Menten Hall (3rd Floor)

https://goo.gl/maps/9LUWXKXj6pv

Abstract:

Management of many bacterial infections is becoming increasingly difficult due to new and rapidly evolving pathogens with increased virulence and drug resistance. Promising alternative approaches to targeting pathogens are to harness the host’s own response to infection or to target virulent processes of the pathogen. To realize these intriguing alternatives, a comprehensive and systematic understanding of the complex dynamics between host and pathogen is required. Using a powerful combination of cutting-edge single cell genetic and genomic approaches, we wish to address what forms the basis for successful immune clearance, from the level of individual infected cells to that of the whole organism, and why, in some cases, sterilization is incomplete?

In this talk, I will demonstrate our approach that applies single cell analysis of models of infection of cultured blood immune cells with different pathogens and of human patient samples. We elucidate the complexity of the human immune system in health and disease, to understand what are the important determinant for successful control of infection. This approach allowed us to identify cell-type specific activation biomarkers that can predict risk to infectious diseases, and also provide indications to changes in immune correlates at very easy stages of infection.

Guest speaker: Steven Altschuler

On February 6th we have another guest speaker. Steven Altschuler from the University of California (http://www.altschulerwulab.org/home)  will give a talk on Cellular decisions in rapidly dividing tissues

Date: February 6th
Time: 4 p.m.
Venue: IRI Life Sciences,
Humboldt-Universität zu Berlin,
Philippstr. 13, Michaelis Building (No 18),
Maud Menten Hall (3rd Floor)
https://goo.gl/maps/9LUWXKXj6pv

 

Cellular decisions in rapidly dividing tissues

We will talk about recent progress in understanding how cells make decisions in rapidly dividing populations. In the first part, we will report on single-cell cancer fate decisions after non-lethal dose of chemotherapy. Chemotherapy is designed to induce cell death. However, at non-lethal doses, cancer cells can choose to remain proliferative or become senescent. The slow development of senescence makes studying this decision challenging. In the second part, we will report on how network crosstalk in the intestinal epithelium regulates cell lineage decisions. We will make use of a novel 2-D gut organoid culture system to dissect how small intestinal epithelium translates combinatorial signals into changes in cell-type composition. Our study helps links the size of the proliferating progenitor compartment with cell-fate specification, enabling a unified and diverse response to the microenvironment.

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About

The research training group CompCancer (RTG2424) is a DFG funded PhD programme in Berlin, focussing on computational aspects of cancer research.

Contact: compcancer at charite dot de