On November 23rd 2021, Tincy defended her thesis “An Integrative Genetic, and Epigenetic Characterization of Pancreatic Neuroendocrine Neoplasms (PanNENs) defines Distinct Molecular Features of Endocrine- and Exocrine-like Subgroups”.
In her work, Tincy analyzed how two sub-entities of PanNENs – so called PanNETs and PanNECs, differ in their DNA methylation patterns and other molecular features. This is important, as high-grade PanNETs are often hard to distinguish from PanNECs by classical morphological analyses used in pathology, yet have a different prognosis and response to specific therapies. Further, Tincy’s work addresses the cell-of-origin of either entity.